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Canadian Journal of Anesthesia, Vol 40, 863-865, Copyright © 1993 by Canadian Anesthesiologists' Society

ARTICLES

Delayed seizures following sedation with propofol

GA Finley, B MacManus, SE Sampson, CV Fernandez and R Retallick
Department of Anaesthesia, Izaak Walton Killam Children's Hospital, Halifax, NS, Canada.

Seizures occurred in two adolescents approximately six hours after sedation with propofol for bone marrow biopsy. Case #1 was a patient with chronic renal failure, hypertension, and anaemia. Case #2 had just been diagnosed with acute lymphocytic leukaemia. Neither child had experienced seizures before, and both recovered without neurological sequelae. Although other factors may have caused the seizures, the episodes have raised concerns about the safety of propofol for patients travelling home after out-patient surgery. Further study is required to explain the cause of this complication or, at least, to identify risk factors.


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