CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Searle, N. R.
Right arrow Articles by Sahab, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Searle, N. R.
Right arrow Articles by Sahab, P.

Canadian Journal of Anesthesia, Vol 39, 838-857, Copyright © 1992 by Canadian Anesthesiologists' Society

ARTICLES

Endothelial vasomotor regulation in health and disease

NR Searle and P Sahab
Departement d'Anesthesie-Reanimation, Institut de Cardiologie de Montreal, Canada.

The purpose of this review is to provide the anaesthetists with a comprehensive update on the endothelial-cell control of local blood flow. This single cell layer was originally thought to represent only a passive barrier. It is now evident that it plays an active role in a broad variety of biological functions. Since the discovery of the endothelial-derived relaxing factor (EDRF), it has been the subject of a considerable amount of research. It is established that EDRF is secreted continuously at a basal state and that many physical stimuli as well as vasoactive substances can modulate its secretion. Evidence presented indicates that the endogenous vasodilatation produced by EDRF is similar to that of the exogenous nitrovasodilator nitroglycerin and nitroprusside (i.e., nitric oxide). Aside from EDRF, the endothelium produces other vasodilating as well as vasoconstricting factors. A review of the physiology of the endothelium regarding the local control of blood flow is provided along with its influence upon several pathophysiological states. Also included is an overview of the influence of anaesthetic agents on endothelial function. These findings linking vasomotor control to endothelial function will help to explain pathophysiological process and may lead to new therapeutic modalities.


This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Lee, D. C. Drinkwater Jr., H. Laks, A. Chong, A. Blitz, M. A. Chen, L. J. Ignarro, and P. Chang
PRESERVATION OF ENDOTHELIUM-DEPENDENT VASODILATION WITH LOW-POTASSIUM UNIVERSITY OF WISCONSIN SOLUTION
J. Thorac. Cardiovasc. Surg., July 1, 1996; 112(1): 103 - 110.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the Canadian Anesthesiologists' Society.