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Canadian Journal of Anesthesia, Vol 37, 202-205, Copyright © 1990 by Canadian Anesthesiologists' Society

ARTICLES

A bolus dose of esmolol attenuates tachycardia and hypertension after tracheal intubation

S Sheppard, CJ Eagle and L Strunin
Department of Anaesthesia, University of Calgary, Foothills Hospital, Alberta.

Forty-five patients of ASA physical status I and II undergoing a variety of non-cardiac surgical procedures were studied to determine the effect of bolus administration of esmolol, a new short-acting beta blocking drug, on heart rate and blood pressure responses to induction of anaesthesia and tracheal intubation. Subjects were allocated randomly to receive placebo, 100 mg or 200 mg of esmolol IV as part of an anaesthetic induction technique. The differences in heart rate between the placebo group and both the 100 mg and 200 mg groups were significant prior to intubation (95 +/- 7.9, 82 +/- 9.7, 80 +/- 7.3 beats per min respectively), and also at 0.5 min and 1.5 min following intubation for the 200 mg group. In the 200 mg group there was a significant decrease, compared with placebo, in systolic blood pressure at 0.5 min (144 +/- 32.1 vs 165 +/- 18.7 mmHg) and 1.5 min (154 +/- 25.0 vs 170 +/- 19.5 mmHg) after intubation. In this study, adequate haemodynamic control was obtained following administration of 200 mg of esmolol.


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J. L. Atlee, M. S. Dhamee, T. L. Olund, and V. George
The Use of Esmolol, Nicardipine, or Their Combination to Blunt Hemodynamic Changes After Laryngoscopy and Tracheal Intubation
Anesth. Analg., February 1, 2000; 90(2): 280 - 280.
[Abstract] [Full Text] [PDF]


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Copyright © 1990 by the Canadian Anesthesiologists' Society.