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Canadian Journal of Anesthesia, Vol 25, 22-25, Copyright © 1978 by Canadian Anesthesiologists' Society

Effect of Anaesthetic Agents on the Ionic Composition of Cerebrospinal Fluid Following Total Cerebral Ischaemia

JOHN G. WADE 1 and SØREN C. SØRENSON 2

1 Department of Anaesthesia, University of Manitoba
2 Institute of Medical Physiology, University of Copenhagen

Total cerebral ischaemia in rats caused a marked increase in the cisternal CSF potassium concentration but little change in CSF sodium or chloride concentration. The anaesthetic techniques studied (pentobarbitone, halothane/oxygen and nitrous oxide/oxygen/relaxant) did not effect the potassium increase following cerebral ischaemia. We conclude that the mechanism of barbiturate protection following cerebral ischaemia is different from that of hypothermia.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.