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Canadian Journal of Anesthesia, Vol 21, 390-402, Copyright © 1974 by Canadian Anesthesiologists' Society

Central Nervous Systems' Effects of Isoflurane (Forane)

EVA M. KAVAN M.D.1 and ROBERT M. JULIEN PH.D.1

1 Department of Medical Pharmacology & Therapeutics, California College of Medicine, University of California, Irvine, Irvine, California 92664

Electrographic effects of isoflurane (Forane) on the CNS were evaluated in chronic and acute experiments. In cats with chronically implanted electrodes, EEG activity was recorded from the cortex and from selected subcortical structures. First changes during inductions of anaesthesia were observed in the structures of the specific somato-sensory system, followed by high voltage spikes in the limbic structures. Continuous hypersynchrony in all leads developed simultaneously with onset of anaesthesia and persisted or developed further into intermittent hypersynchrony during maintenance. Upon termination of inhalation of isoflurane, return to control EEG patterns and behavioural arousal occurred within seconds. In acute preparations, evoked responses recorded in the specific somato-sensory pathways following forepaw stimulation were only slightly affected, but such responses were markedly depressed or abolished in the diffuse reticulo-thalamic activating system.






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Copyright © 1974 by the Canadian Anesthesiologists' Society.