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Canadian Journal of Anesthesia, Vol 21, 131-138, Copyright © 1974 by Canadian Anesthesiologists' Society

Pancuronium and Renal Perfusion: A Comparison of Neuromuscular Blocking Agents

KENNETH M. LEIGHTON M.B., F.R.C.P.(C)1, BEVERLY KOTH , and CAROLINE BRUCE (HONS.) B.SC.(ST. AND.)

1 Departments of Anaesthesia and Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver 8, B.C.

Neuromuscular blocking agents in general have moderate to marked cardiovascular effects. Pancuronium, a recently introduced neuromuscular blocker, appears to have effects which are stimulatory, rather than inhibitory, upon the cardiovascular system and these effects are, in general, but slight. A study of pancuronium, succinylcholine, d-tubocurare and gallamine in the presence of halothane, methoxyflurane and alphaprodine suggests that the effect of pancuronium upon renal blood flow is negligible and that this is not the case for succinylcholine or d-tubocurare. Gallamine also has minimal effects upon renal blood flow, but has its own well-documented problems in the presence of severe renal dysfunction.






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Copyright © 1974 by the Canadian Anesthesiologists' Society.