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Canadian Journal of Anesthesia, Vol 13, 557-561, Copyright © 1966 by Canadian Anesthesiologists' Society

Serum Cholinesterase in Anaesthesia With Reference to Neostigmine, Fentanyl, and Dihydrobenzpiridol

J.W. R. MCINTYRE F.F.A.R.C.S.1 and D. J. CAMPBELL PH.D.1

1 Departments of Anaesthesia and Clinical Laboratory Services, University of Alberta Hospital, Edmonton, Alberta

The activity of serum cholinesterase has been measured prior to and following e surgery in patients anaesthetized with a nitrous oxide, fentanyl, droperidol, or halothane technique. Except in one case no significant changes occurred. Neostigmine reduced enzyme activity to a low level in some patients. This occurrence might have a clinically significant effect on the quantity of any neostigmine administered subsequently that would be sufficient to produce depression of neuromuscular transmission, and on the rate of inactivation of those drugs affected by this enzyme.






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Copyright © 1966 by the Canadian Anesthesiologists' Society.