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Canadian Journal of Anesthesia, Vol 11, 496-502, Copyright © 1964 by Canadian Anesthesiologists' Society

The Effect of Epinephrine on Anaesthetized Hyperthyroid Dogs Pretreated with Reserpine and/or Guanethidine

PETER KWANG-YI LEE MD1, JACOB S ISRAEL MD, and ALLEN B DOBKIN MD

1 Postdoctoral Research Fellow

Dogs made hyperthyroid with Protamone were anaesthetized with thiopentone and methoxyflurane after pretreatment with either guanethidine and/or reserpine. They were then given a standard epinephrine challenge. Ventricular fibrillation and other severe ventricular arrhythmias were seen more frequently in all of these animals than was observed in previous studies of hyperthyroid dogs anaesthetized with methoxyflurane, but not pretreated with reserpine and/or guanethidine.

Thus, by inference from the literature reviewed and the experimental work of this paper, it would appear to be extremely dangerous to administer epinephrine to hyperthyroid patients while they are receiving guanethidine and/or reserpine therapy

Note:

From the Department of Anesthesiology, State University of New York, Upstate Medical Center, Syracuse, New York






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Copyright © 1964 by the Canadian Anesthesiologists' Society.