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Canadian Journal of Anesthesia, Vol 1, 95-103, Copyright © 1954 by Canadian Anesthesiologists' Society

A Study of the Value of Dimenhydrinate and Promethazine Hydrochloride in the Control of Post-Anaesthetic Vomiting

R. A. GORDON M.D., F.R.C.P.(C), F.F.A.R.C.S.1, S. L. VANDEWATER M.D., F.R.C.P.(C)1, G. E. SLEATH B.A., M.D.1, and DOREEN CAPLIN M.D.1

1 Department of Anaesthesia, Faculty of Medicine, University of Toronto

The routine use of Dimenhydrinate ("Gravol", "Dramamine") and of Promethazine HCl ("Phenergan") in the prevention of post-operative vomiting has been studied, using the drugs according to the dosage scale recommended by the manufacturers at the time this study was undertaken. The incidence of vomiting in these patients was compared with suitable control groups who did not receive the drug. Dimenhydrinate was given to surgical patients only, while Promethazine HCl was also tested in a single dose series on obstetrical patients. In the obstetrical group it was demonstrated that in the dosage used Promethazine HCl did not depress the infant.

It is concluded that while Dimenhydrinate appears to suppress post-operative vomiting to some extent, the results in this study do not have sufficient statistical significance to warrant its use as a routine measure on a surgical service. Promethazine HCl produced a very significant reduction in vomiting under the conditions of this study, and probably warrants further use as a prophylactic measure against post-operative vomiting.

Note:

Presented at the Annual Meeting, Canadian Anaesthetists' Society, at Vancouver, British Columbia, June 14, 1954.






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Copyright © 1954 by the Canadian Anesthesiologists' Society.